Document Type : Research Paper
The binding data for interaction of a homologous series of n-alkyl sulfates with alkyl chain
lengths from C8 to C12 with insulin were analyzed on basis of Hill equation for two classes of
binding sites .The intrinsic Gibbs free energies were calculated and resolute on basis of
electrostatic and hydrophobic contributions The estimation of these contributions reveals the
major role of electrostatic interactions on first binding set and the minor one in the second.