The kinetic parameters of drug compounds adsorption onto mesoporous materials

Document Type : Research Paper




The discovery of mesoporous molecular sieves, MCM-41, which possesses a regular hexagonal
array of uniform pore openings, aroused a worldwide resurgence in this field. This is not only
because it has brought about a series of novel mesoporous materials with various compositions
which may find applications in catalysis, adsorption, and guest-host chemistry, but also it has
opened a new avenue for creating of the zeotype materials. This paper presents a comprehensive
overview of recent advances in the field of MCM-41. Adsorption of drug molecules such as
Pseudeoephedrine hydrochloride onto mesoporous molecular sieves (MCM-41) from aqueous
solution has been investigated systematically using batch experiments in this study. Results
indicate that Pseudeoephedrine hydrochloride adsorption is initially rapid and the adsorption
process reaches a steady state after 2 min. The adsorption isotherms are well described by the
Langmuir model. Based on the results, it suggests that the adsorption is primarily brought about by
hydrophobic interaction between drug molecules and MCM-41 surface.